C-X-C Motif Chemokine Ligand 6: A Preoperative Biomarker for Recurrent Glioblastoma Multiforme

To explore the function of C-X-C motif chemokine ligand as a prospective early biomarker for recurrent glioblastoma multiforme is objective study. The differentially expressed genes patients were systematically explored; gene ontology and Kyoto encyclopedia genomes enrichment analysis potential hub was established; functional network developed by protein-protein interaction method. cell line U251 established in vitro experiments; wound healing assay well transwell conducted to measure tumor properties cells. expression 6 significantly higher than non-recurrent (p<0.05), suggesting an independent prognostic indicator recurrence. Based on 6, programmed death ligand-1 signal transducer activator transcription 3 signaling primarily associated with 6. over-expression treatments induced markedly enhanced levels phospho-signal 3. At same time, regulation cells dependent since silencing obviously attenuated functions over-expression. Moreover, it could be implied that linked status patients, their remarkably accelerated patients. This integrated study provided offered beneficial references future clinical administration evaluation multiforme.